Cancer

A cell becomes cancerous when enough changes turn the cell to uncontrolled growth and cellular division. There is a classical view of cancer in which the disease arises via genetic mutations. These mutations cause changes in genes that can make the protein non-functional or over active that lead to a cancerous state. But there is no set number of mutations that must be registered, but rather the trigger point depends on what genes are affected and in what cell type. Epigenetic changes affect cell behavior and division and it is becoming abundantly clear that cells can become cancerous from epigenetic changes as well. For example, hypermethylation of a gene important for DNA repair could inhibit the protein’s activity. As our understanding of how epigenetic changes induce cancerous changes increases, new drugs, treatment protocols and diagnostic tools are being released to improve care.

Understanding Epigenetics:
Cancer
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Video: How epigenetic changes cause cancer
| Garvan Institute of Medical Research
Epigenetics: Core misconcept
Mark Ptashne | Proceedings of the National Academy of Sciences
Research
SMYD2 is a novel epigenetic regulator of cyst growth
July 06, 2017 | Andrea Aguilar | Nature Reviews Nephrology
Cancer Epigenetics: Therapy-induced transcription is cryptically widespread
June 27, 2017 | Darren Burgess | Nature Reviews Genetics
Click chemistry enables preclinical evaluation of targeted epigenetic therapies
June 20, 2017 | Dean S. Tyler, Johanna Vappiani | Science
Propagation of Polycomb-repressed chromatin requires sequence-specific recruitment to DNA
June 08, 2017 | Friederike Laprell, Katja Finkl, Jürg Müller | Science
Associating cellular epigenetic models with human phenotypes
June 06, 2017 | Tuuli Lappalainen, John M. Greally | Nature
Epigenomics, pharmacoepigenomics, and personalized medicine in cervical cancer
May 25, 2017 | Shama Prasada Kabekkodu | Public Health Genomics