How epigenetics, proteins work together to regulate gene expression
Avaneesh Pandey| International Business Times | May 08, 2017

In a new study published in the journal Science, a team of researchers has described how DNA-binding proteins (called transcription factors) react to and interpret these “epigenetic” changes. The study reveals that certain “master” regulatory proteins can activate regions of the genome that are normally inactive.

“This study identifies how the modification of the DNA structure affects the binding of transcription factors, and this increases our understanding of how genes are regulated in cells and further aids us in deciphering the grammar written into DNA,” study co-author Jussi Taipale from Karolinska Institutet in Sweden said in a statement.

The researchers found that while most transcription factors are incapable of binding to DNA sequences containing methylated cytosine, some transcription factors actually prefer the methylated version, including some factors that play a key role in embryonic development, and in the development of prostate and colorectal cancers.

“The results suggest that such ‘master’ regulatory factors could activate regions of the genome that are normally inactive, leading to the formation of organs during development, or the initiation of pathological changes in cells that lead to diseases such as cancer,” Taipale said.

The ELP aggregated and excerpted this blog/article to reflect the diversity of news, opinion, and analysis. Read full, original post: Scientists Study How DNA-Binding Proteins Read, Interpret ‘Epigenetic’ Changes

Want to stay up to date on the latest epigenetics news? Follow ELP on Twitter and like the Facebook