Phthalates may increase risk of allergies among children, mouse study finds
Helmholtz Centre For Environmental Research | May 17, 2017

Phthalates, which are used as plasticizers in plastics, can considerably increase the risk of allergies among children.

At the outset of the study, the team of UFZ researchers examined the urine of pregnant women from the LINA (lifestyle and environmental factors and their influence on the newborn-allergy-risk) mother-child cohort study and searched for metabolites of phthalates. The concentration level determined in each case was found to correlate with the occurrence of allergic asthma among the children. “There was a clearly discernible relationship between higher concentrations of the metabolite of nvironmental factors and their influence on the newborn-allergy-risk) mother-child cohort study and searched for metabolites of phthalates. The concentration level determined in each case was found to correlate with the occurrence of allergic asthma among the children. “There was a clearly discernible relationship between higher concentrations of the metabolite of benzylbutylphthalate (BBP) in the mother’s urine and the presence of allergic asthma in their children,” explains Dr Irina Lehmann, who heads the LINA study.

Researchers were able to confirm the results from the mother-child cohort in the mouse model in collaboration with colleagues from the Medical Faculty at the University of Leipzig. In this process, mice were exposed to a certain phthalate concentration during pregnancy and the lactation period, which led to comparable concentrations of the BBP metabolite in urine to those observed in heavily exposed mothers from the LINA cohort. The offspring demonstrated a clear tendency to develop allergic asthma.

The ELP aggregated and excerpted this blog/article to reflect the diversity of news, opinion, and analysis. Read full, original post: Phthalates increase the risk of allergies among children

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